The journal publishes original research reports, authoritative reviews, technical developments and commissioned book reviews of studies of the effects produced by low temperatures on a wide variety of scientific and technical processes, or those involving low temperature techniques in the investigation of physical, chemical, biological and ecological problems. CryoLetters is particularly keen to keep a broad view of low temperature science and technology, and therefore welcomes papers which bridge disciplines and may not suit the narrow specialism of other journals. Although the general emphasis is on biological sciences, physical and chemical aspects are published often where they have a particular application in cryobiology. Aspects of temperature acclimation and hibernation are welcome as are scientific studies of supercooling and vitrification. Studies of hibernation and other adaptations to cold climates are clearly within our remit.

該期刊發表原創研究報告，權威評論，技術發展和委托書評，研究低溫對各種科學和技術過程產生的影響，或涉及低溫技術的物理，化學，生物學研究 和生態問題。 CryoLetters特別熱衷于保持低溫科學和技術的廣泛視野，因此歡迎那些跨學科的論文，可能不適合其他期刊的狹隘專業。 雖然一般強調的是生物科學，但物理和化學方面經常出現在它們在低溫生物學中具有特定應用的地方。 溫度馴化和冬眠的方面以及過冷和玻璃化的科學研究都是受歡迎的。 關于冬眠和其他適應寒冷氣候的研究顯然屬于我們的職權范圍。