Computational Biology and Chemistry publishes original research papers and review articles in all areas of computational life sciences. High quality research contributions with a major computational component in the areas of nucleic acid and protein sequence research, molecular evolution, molecular genetics (functional genomics and proteomics), theory and practice of either biology-specific or chemical-biology-specific modeling, and structural biology of nucleic acids and proteins are particularly welcome. Exceptionally high quality research work in bioinformatics, systems biology, ecology, computational pharmacology, metabolism, biomedical engineering, epidemiology, and statistical genetics will also be considered.Given their inherent uncertainty, protein modeling and molecular docking studies should be thoroughly validated. In the absence of experimental results for validation, the use of molecular dynamics simulations along with detailed free energy calculations, for example, should be used as complementary techniques to support the major conclusions. Submissions of premature modeling exercises without additional biological insights will not be considered.Review articles will generally be commissioned by the editors and should not be submitted to the journal without explicit invitation. However prospective authors are welcome to send a brief (one to three pages) synopsis, which will be evaluated by the editors.

計(jì)算生物學(xué)和化學(xué)在計(jì)算生命科學(xué)的所有領(lǐng)域出版原始研究論文和評(píng)論文章。特別歡迎在核酸和蛋白質(zhì)序列研究、分子進(jìn)化、分子遺傳學(xué)(功能基因組學(xué)和蛋白質(zhì)組學(xué))、生物特異性或化學(xué)生物特異性建模的理論和實(shí)踐以及核酸和蛋白質(zhì)的結(jié)構(gòu)生物學(xué)等領(lǐng)域提供高質(zhì)量的研究成果，這些研究成果是計(jì)算方面的重要組成部分。在生物信息學(xué)、系統(tǒng)生物學(xué)、生態(tài)學(xué)、計(jì)算藥理學(xué)、代謝、生物醫(yī)學(xué)工程、流行病學(xué)和統(tǒng)計(jì)遺傳學(xué)方面的高質(zhì)量研究工作也將被考慮。鑒于它們固有的不確定性，蛋白質(zhì)模型和分子對(duì)接研究應(yīng)該得到徹底的驗(yàn)證。在缺乏實(shí)驗(yàn)結(jié)果進(jìn)行驗(yàn)證的情況下，例如，應(yīng)該使用分子動(dòng)力學(xué)模擬和詳細(xì)的自由能計(jì)算作為補(bǔ)充技術(shù)來(lái)支持主要結(jié)論。沒(méi)有額外的生物學(xué)見解的不成熟的模型練習(xí)的提交將不被考慮。評(píng)審文章一般由編輯委托撰寫，未經(jīng)明確邀請(qǐng)不得投稿。然而，歡迎未來(lái)的作者發(fā)送一個(gè)簡(jiǎn)短的(一到三頁(yè))概要，這將由編輯進(jìn)行評(píng)估。